Analyses biologiques par spectrométrie de masse

Le groupe AnabioMS propose des développements en spectrométrie de masse pour l’analyse structurale et quantitative de biomolécules (protéines, peptides, lipides et/ou métabolites), dans des matrices complexes, le plus souvent d’origine biologique (cellules, organismes, sang…). Les objectifs poursuivis sont: i) l’amélioration des performances analytiques en termes de résolution, de spécificité et de gamme dynamique de détection, de capacité de multiplexage; ii) la découverte et la validation de biomarqueurs ; iii) le transfert de méthodes de dosages en clinique ou en suivi environnemental.

Axes de recherche

  • Découverte et validation de candidats biomarqueurs protéiques pour la santé humaine (infection, vieillissement, etc.) et pour la surveillance environnementale (chez les espèces sentinelles), sur la base de nouveaux concepts logiciels et de procédures analytiques ciblées (J. Lemoine, A. Salvador).

L’augmentation de l’incidence de la résistance aux antibiotiques constitue une menace majeure en santé humaine. Établir rapidement un diagnostic dans le contexte d’une infection permet à la fois une meilleure prise en charge du patient et de limiter le risque d’émergence de micro-organismes résistants. L’équipe développe de nouvelles approches protéomiques ascendantes en spectrométrie de masse, basse et haute résolution, permettant d’identifier des micro-organismes dans des prélèvements biologiques, et de quantifier la présence éventuelle d’un ou plusieurs mécanismes de résistance aux antimicrobiens. L’objectif ultime est de transférer ces méthodes en environnement clinique et de les industrialiser (start-up Weezion).

  • Augmentation de la spécificité et simplification de l’échantillonnage de mélanges complexes par le développement d’une nouvelle stratégie basée sur la photo-dissociation laser visible couplée à la spectrométrie de masse à haute résolution (M. Girod).

Afin d’améliorer la spécificité de détection de composés ciblés faiblement concentrés, nous avons développé un montage expérimental novateur, couplant la spectrométrie de masse et la photodissociation laser (LID) dans le visible afin d’ajouter une spécificité optique à la sélectivité en masse. Comme les peptides n’absorbent pas naturellement dans le domaine du visible, cette nouvelle approche s’appuie sur la dérivatisation spécifique des composés ciblés avec un chromophore pour leur conférer une réactivité de photodissociation laser à 473 nm. Seuls les peptides dérivés seront spécifiquement fragmentés en LID, améliorant les performances de dosage de protéines oxydées dans des échantillons biologiques. Nous avons en particulier appliqué cette stratégie pour l’analyse des oxydations des cystéines et la carbonylation des protéines dans un contexte de stress oxydant.

  • Développement d’approches multi-omiques intégrées en Environnement et en Santé et applications en imagerie MS (S. Ayciriex, A. Salvador).

Les approches multi-omiques ont pour objectif l’exploration simultanée de plusieurs « omiques », tels que la génomique, la transcriptomique, la protéomique, la métabolomique et bien d’autres. Ces approches sont conçues pour offrir une vision holistique permettant de mieux comprendre les interactions complexes qui règnent entre les différents niveaux d’information moléculaire au sein d’un système biologique. Dans ce contexte, notre intérêt s’est porté sur le développement de méthodes analytiques innovantes pour les approches multi-omiques (protéomique, lipidomique et métabolomique) allant de l’optimisation de la préparation des échantillons, de l’acquisition de la donnée « omique » en spectrométrie de masse haute résolution ou ciblée (approche DIA, Scout-MRM), des analyses statistiques multivariées avec l’intégration des données par des approches de machine learning (en collaboration avec la plateforme Chemod ISA). Ces développements permettent ainsi d’obtenir des informations précieuses sur les mécanismes biologiques, les maladies, les réponses à des contaminants en santé environnementale et en santé humaine.

De plus l’apport des techniques d’imagerie par MS (MALDI, ToF-SIMS) est extrêmement bénéfique dans le contexte des approches multi-omiques, en fournissant d’une part la localisation spatiale des molécules, et permettant d’autre part d’identifier de nouveaux composés jamais caractérisés chez un organisme sentinelle par exemple.

Projets de recherche

IHU EVEREST – intEgratiVE RESearch in HepaTology (Janv. 2024- Dec. 2034)
Financé par l’Agence Nationale de la Recherche, Instituts Hospitalo-Universitaires (IHU-3)
Coordinateur: Prof. F. Zoulim (Institut d’hépathologie de Lyon, IHL ; Hospices Civils de Lyon HCL), Consortium : Institut des Sciences Analytiques (S. Ayciriex), CRCL, CarMeN, NUDICE, CIRI, CBMS, LBBE, RESHAPE, U1296 « Radiations : Défense, Santé Environnement »)

IdBIORIV – Concomitant Identification, AntiBIOtic ResIstance and Virulence evaluation of bacterial pathogens with targeted mass spectrometry (2019-2026)
Financé par l’Agence Nationale de la Recherche ; Recherches Hospitalo-universitaires en santé  (RHU) ; https://anr.fr/ProjetIA-18-RHUS-0013
Coordinateur : Prof. F. Vandenesch (Hospices Civils de Lyon HCL) – Consortium: Institut des Sciences Analytiques (J. Lemoine), AB SCIEX

IDAREV – Identification, caractérisation de la résistance aux antibiotiques et évaluation de la virulence de bactéries de manière concomitante par spectrométrie de masse ciblée adaptative (nov. 2019 – octobre 2023, ANR PRC)
Financé par l’Agence Nationale de la Recherche ; https://anr.fr/Projet-ANR-19-CE19-0016
Coordinateur : J. Lemoine (ISA UMR 5280) – Consortium: Centre International de Recherche en Infectiologie, Microbes Intestin Inflammation et Susceptibilité de l’Hôte, CHU Rennes – Hôpital Pontchaillou (CHU Rennes), Laboratoire ChronoEnvironnment (UMR 6249 CNRS-UFC)

IDAREMS – Concomitant IDentification and Antibiotic REsistance profile of bacteria in one hour with an adaptive targeted single Mass Spectrometry analysis (mars 2020 – fevr. 2024)
Financé par Joint Programming Initiative on Antimicrobial Resistance (JPIAMR); https://www.jpiamr.eu/projects/idarems/
Coordinateur : J. Lemoine (ISA UMR 5280) – Consortium international: Pologne, Thailande.

APPROve – Integrated Approach to Propose PRoteomics for biOmonitoring: accumulation, fate and multi-markers (dec. 2018 – dec 2023, ANR PRCE)
Financé par l’Agence Nationale de la Recherche, https://anr.fr/Projet-ANR-18-CE34-0013
Coordinateur : O. Geffard (INRAe) – Consortium: Institut des Sciences Analytiques (A. Salvador), Laboratoire de Biométrie et Biologie Evolutive (UMR  5558 CNRS), Institut des sciences du vivant Frédéric-Joliot (CEA), BIOMAE, LIENSs (UMR 7266 CNRS)

HyLOxi – Approche couplée laser-MS pour la caractérisation du stress oxydant (sept. 2018 – dec 2022, ANR JCJC)
Financé par l’Agence Nationale de la Recherche, https://anr.fr/Projet-ANR-18-CE29-0002
Coordinatrice: M. Girod (ISA)

PLAN-TOX – Approches Protéomique et Lipidomique pour la compréhension des mécanismes moléculaires de toxicité en lien avec l’altération du métabolisme lipidique chez l’espèce sentinelle Gammarus fossarum durant le cycle de reproduction (dec. 2018 – dec. 2022, ANR JCJC)
Financé par l’Agence Nationale de la Recherche, https://anr.fr/Projet-ANR-18-CE34-0008
Coordinatrice: S. Ayciriex (ISA)

Partenariats

– Institut des agents infectieux, Centre national de référence des staphylocoques HCL Lyon Nord (Prof. F. Vandenesch)

– Analyse de taux d’oxydation des cystéines par LID-MS/MS dans des sérums de patients positifs au COVID-19 (Prof. S. Assant)

– Service d’hépatologie et gastroentérologie HCL Lyon Nord (Prof. F. Zoulim, Prof. M. Levrero, Prof. J-Y. Mabrut)

– Service d’Endocrinologie-Diabète-Nutrition HCL Lyon sud (Prof. C. Caussy)

– Service de chirurgie uro-viscérale, thoracique et de transplantation de l’enfant (Prof. P-Y Mure)

– Service de chirurgie générale, digestive et transplantations hépatiques et intestinales (Dr. G. Rossignol)

L’équipe AnabioMS collabore depuis plus de 10 ans avec le Laboratoire de Chimie (CNRS / Ens Lyon / université Lyon1) pour la synthèse de chromophores.
L’équipe AnabioMS collabore depuis plus de 15 ans avec le Laboratoire d’écotoxicologie en développant et transférant différentes approches analytiques innovantes pour l’espèce sentinelle Gammarus Fossarum.

L’équipe AnabioMS a également contracté de nombreux partenariats avec des sociétés pharmaceutiques, diagnostiques ou biotechnologiques (Sanofi, bioMérieux).

Capacités expérimentales et instrumentales

  • 2 API 6500 QTRAP (Sciex) couplés à un système HPLC
  • 2 API 5500 QTRAP (Sciex) couplés à un système HPLC
  • ZenoTOF 7600 (Sciex) avec fragmentation EAD couplés à un système HPLC, nanoHPLC et EVOSEP
  • QExactive Orbitrap (ThermoFisher) haute résolution avec photo-dissociation laser couplé à un système HPLC
  • 2 API 4000 QTRAP (Sciex) couplés à un système HPLC

Automate d’extraction : Beckman Coulter Biomek NX et Biomek 4000

Personnels

  • Chercheurs et enseignants-chercheurs

    • Sophie AYCIRIEX
    • Marion GIROD
    • Jérôme LEMOINE
    • Arnaud SALVADOR
  • Soutien à la recherche

    • Delphine ARQUIER
    • Romain CARRIERE
  • Post-doctorants

    • Valentina CALABRESE
  • Doctorants

    • Thomas BRUNET
    • Rémy DE BONI
    • Agnès DUPAS
    • Julie FLECHEUX
    • Pierre L'AOUR DUFOUR
    • Iulia MACAVEI
    • Annabelle MÉDALIN
    • Léo SCHNEIDER
  • Autres

    • Pénélope BOURMAUD-CADIOT

Publications (sources HAL)

Articles dans une revue

  • Natacha Koenig, Patrice Baa-Puyoulet, Amélie Lafont, Isis Lorenzo-Colina, Vincent Navratil, et al.. Proteogenomic reconstruction of organ-specific metabolic networks in an environmental sentinel species, the amphipod Gammarus fossarum. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2024, 52, pp.101323. ?10.1016/j.cbd.2024.101323?. ?hal-04704294?
  • Francis Deforet, Romain Carrière, Pierre L.’aour Dufour, Roxane Prat, Chloé Desbiolles, et al.. Proteomic assay for rapid characterisation of Staphylococcus aureus antimicrobial resistance mechanisms directly from blood cultures. European Journal of Clinical Microbiology and Infectious Diseases, 2024, ?10.1007/s10096-024-04811-0?. ?hal-04615636?
  • Thomas Alexandre Brunet, Yohann Clément, Valentina Calabrese, Jérôme Lemoine, Olivier Geffard, et al.. Concomitant investigation of crustacean amphipods lipidome and metabolome during the molting cycle by Zeno SWATH data-independent acquisition coupled with electron activated dissociation and machine learning. Analytica Chimica Acta, 2024, 1304, pp.342533. ?10.1016/j.aca.2024.342533?. ?hal-04535105?
  • Tingting Fu, Valentina Calabrese, Anabelle Espeyte, Sarah Bancel, Hervé Quéau, et al.. ToF-SIMS imaging shows specific lipophilic vitamin alterations in chronic reprotoxicity caused by the emerging contaminant Pravastatin in Gammarus fossarum.. Aquatic Toxicology, 2024, 271, pp.106935. ?10.1016/j.aquatox.2024.106935?. ?hal-04565127?
  • Valentina Calabrese, Thomas Alexandre Brunet, Davide Degli-Esposti, Arnaud Chaumot, Olivier Geffard, et al.. Electron-activated dissociation (EAD) for the complementary annotation of metabolites and lipids through data-dependent acquisition analysis and feature-based molecular networking, applied to the sentinel amphipod Gammarus fossarum. Analytical and Bioanalytical Chemistry, 2024, 416 (12), pp.2893-2911. ?10.1007/s00216-024-05232-w?. ?hal-04507595?
  • Mukesh Kumar, Canan Has, Khanh Lam-Kamath, Sophie Ayciriex, Deepshe Dewett, et al.. Lipidome Unsaturation Affects the Morphology and Proteome of the Drosophila Eye. Journal of Proteome Research, 2024, ?10.1021/acs.jproteome.3c00570?. ?hal-04519027?
  • Guillaume Rossignol, Xavier Muller, Thomas Alexandre Brunet, Valeska Bidault, Valerie Hervieu, et al.. Comprehensive bile acid pool analysis during ex-vivo liver perfusion in a porcine model of ischemia-reperfusion injury. Scientific Reports, 2024, 14 (1), pp.2384. ?10.1038/s41598-024-52504-7?. ?hal-04425302?
  • Patricia Laquel, Sophie Ayciriex, François Doignon, Nadine Camougrand, Louise Fougère, et al.. Mlg1, a yeast acyltransferase located in ER membranes associated with mitochondria ( MAMs ), is involved in de novo synthesis and remodelling of phospholipids. FEBS Journal, In press, ?10.1111/febs.17068?. ?hal-04431763?
  • Marion Girod, Delphine Arquier, Amanda Helms, Kyle Juetten, Jennifer S Brodbelt, et al.. Characterization of Phosphorylated Peptides by Electron-Activated and Ultraviolet Dissociation Mass Spectrometry: A Comparative Study with Collision-Induced Dissociation. Journal of The American Society for Mass Spectrometry, 2024, 35 (5), pp.1040-1054. ?10.1021/jasms.4c00048?. ?hal-04615633?
  • Vijaykumar Patra, Natalie Bordag, Yohann Clément, Harald Köfeler, Jean-Francois Nicolas, et al.. Ultraviolet exposure regulates skin metabolome based on the microbiome. Scientific Reports, 2023, 13 (1), pp.7207. ?10.1038/s41598-023-34073-3?. ?hal-04091111?
  • Francis Deforet, Quentin Jehanne, Lucie Bénéjat, Johanna Aptel, Roxane Prat, et al.. Combined genomic-proteomic approach in the identification of Campylobacter coli amoxicillin-clavulanic acid resistance mechanism in clinical isolates. Frontiers in Microbiology, 2023, 14, ?10.3389/fmicb.2023.1285236?. ?hal-04615631?
  • Maxime Leprêtre, Arnaud Chaumot, Rayan Aboud, Nicolas Delorme, Anabelle Espeyte, et al.. Dynamic Multiple Reaction Monitoring of amphipod Gammarus fossarum caeca expands molecular information for understanding the impact of contaminants. Science of the Total Environment, 2023, 893, pp.164875. ?10.1016/j.scitotenv.2023.164875?. ?hal-04460286?
  • Romain Ladouce, Luke Macaleese, Karlo Wittine, Mladen Merćep, Marion Girod. Specific detection of protein carbonylation sites by 473 nm photodissociation mass spectrometry. Analytical and Bioanalytical Chemistry, 2023, ABC Highlights: authored by Rising Stars and Top Experts, ?10.1007/s00216-023-04956-5?. ?hal-04237901?
  • Thomas Alexandre Brunet, Sophie Ayciriex, Delphine Arquier, Jérôme Lemoine, Jérôme Randon, et al.. Scout triggered multiple reaction monitoring mass spectrometry for the rapid transfer of large multiplexed targeted methods in metabolomics.. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2023, 1228, pp.123849. ?10.1016/j.jchromb.2023.123849?. ?hal-04216213?
  • Julien Faugere, Thomas Alexandre Brunet, Yohann Clément, Anabelle Espeyte, Olivier Geffard, et al.. Development of a multi-omics extraction method for ecotoxicology: investigation of the reproductive cycle of Gammarus fossarum. Talanta, 2023, 253, pp.123806. ?10.1016/j.talanta.2022.123806?. ?hal-03773623?
  • Valentina Calabrese, Arnaud Salvador, Yohann Clément, Thomas Alexandre Brunet, Anabelle Espeyte, et al.. Challenges and perspectives in MS-based omics approaches for ecotoxicology studies: An insight on Gammarids sentinel amphipods. Frontiers in Analytical Science, 2023, 3, pp.1118494. ?10.3389/frans.2023.1118494?. ?hal-03986050?
  • Yoan Monneau, Cyrielle Arrault, Coraline Duroux, Marie Martin, Fabien Chirot, et al.. Structural and dynamical insights into SilE silver binding from combined analytical probes. Physical Chemistry Chemical Physics, 2023, 25 (4), pp.3061-3071. ?10.1039/D2CP04206A?. ?hal-03960103?
  • Sophie Ayciriex. Meet up‐and‐coming analytical scientists – Sophie Ayciriex. Analytical Science Advances, 2022, ?10.1002/ansa.202200043?. ?hal-03893334?
  • Aurélien Scalabre, Yohann Clément, Florence Guillière, Sophie Ayciriex, Ségolène Gaillard, et al.. Early detection of ureteropelvic junction obstruction in neonates with prenatal diagnosis of renal pelvis dilatation using 1H NMR urinary metabolomics. Scientific Reports, 2022, 12 (1), pp.13406. ?10.1038/s41598-022-17664-4?. ?hal-03745903?
  • Mukesh Kumar, Canan Has, Khanh Lam-Kamath, Sophie Ayciriex, Deepshe Dewett, et al.. Vitamin A Deficiency Alters the Phototransduction Machinery and Distinct Non-Vision-Specific Pathways in the Drosophila Eye Proteome. Biomolecules, 2022, 12 (8), pp.1083. ?10.3390/biom12081083?. ?hal-03751366?
  • Jean-Valery Guillaubez, Delphine Pitrat, Yann Bretonnière, Jérôme Lemoine, Marion Girod. Relative quantification of sulfenic acids in plasma proteins using differential labelling and mass spectrometry coupled with 473 nm photo-dissociation analysis: A multiplexed approach applied to an Alzheimer's disease cohort. Talanta, 2022, 250, pp.123745. ?10.1016/j.talanta.2022.123745?. ?hal-03740463?
  • Maxence Wilmet, Clément Lebastard, Flavien Sciortino, Clothilde Zerbino, Luke Macaleese, et al.. Revisiting Properties of Edge-Bridged Bromide Tantalum Clusters in the Solid-State, in Solution and vice-versa: An Intertwined Experimental and Modelling Approach. Dalton Transactions, 2021, 50 (23), pp.8002-8016. ?10.1039/D0DT04200E?. ?hal-03208710?
  • Chloé Bardet, Olivier Barraud, Marc Clavel, Tanguy Fortin, Jean-Philippe Charrier, et al.. Early and specific targeted mass spectrometry-based identification of bacteria in endotracheal aspirates of patients suspected with ventilator-associated pneumonia. European Journal of Clinical Microbiology and Infectious Diseases, 2021, 40 (6), pp.1291-1301. ?10.1007/s10096-020-04132-y?. ?hal-03318498?
  • Guillaume F Combes, Hussein Fakhouri, Christophe Moulin, Marion Girod, Franck Bertorelle, et al.. Functionalized Au15 nanoclusters as luminescent probes for protein carbonylation detection. Communications Chemistry, 2021, 4, pp.69. ?10.1038/s42004-021-00497-z?. ?hal-03234146?
  • Simon Dörner, Lucas Schwob, Kaja Schubert, Marion Girod, Luke Macaleese, et al.. The influence of the methionine residue on the dissociation mechanisms of photoionized methionine-enkephalin probed by VUV action spectroscopy. The European Physical Journal D : Atomic, molecular, optical and plasma physics, 2021, 75 (4), ?10.1140/epjd/s10053-021-00147-y?. ?hal-03343271?
  • Jean-Valery Guillaubez, Delphine Pitrat, Yann Bretonnière, Jérôme Lemoine, Marion Girod. Unbiased Detection of Cysteine Sulfenic Acid by 473 nm Photodissociation Mass Spectrometry: Toward Facile In Vivo Oxidative Status of Plasma Proteins. Analytical Chemistry, 2021, 93 (5), pp.2907-2915. ?10.1021/acs.analchem.0c04484?. ?hal-03151805?
  • Damien Fournier, Romain Carrière, Maxime Bour, Emilie Grisot, Pauline Triponney, et al.. Mechanisms of Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa: Results of the GERPA Multicenter Study. Antimicrobial Agents and Chemotherapy, 2021, 65 (2), ?10.1128/AAC.01117-20?. ?hal-04001419?
  • Aurélien Le Fèvre, Philippe Dugourd, Fabien Chirot. Exploring Conformational Landscapes Using Trap and Release Tandem Ion Mobility Spectrometry. Analytical Chemistry, 2021, 93 (9), pp.4183-4190. ?10.1021/acs.analchem.0c04520?. ?hal-03151840?
  • Frank Gondelaud, Mathilde Bouakil, Aurélien Le Fèvre, Adriana Erica Miele, Fabien Chirot, et al.. Extended disorder at the cell surface: The conformational landscape of the ectodomains of syndecans. Matrix Biology Plus, 2021, 12 (3-4), pp.100081. ?10.1016/j.mbplus.2021.100081?. ?hal-04004263?
  • Kaja Schubert, Lucas Schwob, Simon Dörner, Marion Girod, Luke Macaleese, et al.. Ionization and Photofragmentation of Isolated Metalloporphyrin Cations Investigated by VUV Action Spectroscopy. Chemistry - A European Journal, 2021, 27 (48), pp.12371-12379. ?10.1002/chem.202101515?. ?hal-03295602?
  • Tingting Fu, Oskar Knittelfelder, Yohann Clément, Eric Testet, Nicolas Elie, et al.. Shotgun lipidomics and mass spectrometry imaging unveil diversity and dynamics in Gammarus fossarum lipid composition. iScience, 2021, 24 (2), pp.1-44. ?10.1016/j.isci.2021.102115?. ?hal-03134038?
  • Maxime Leprêtre, Nicole Faury, Amélie Segarra, Stéphane Claverol, Lionel Degremont, et al.. Comparative Proteomics of Ostreid Herpesvirus 1 and Pacific Oyster Interactions With Two Families Exhibiting Contrasted Susceptibility to Viral Infection. Frontiers in Immunology, 2021, 11, pp.621994. ?10.3389/fimmu.2020.621994?. ?hal-04460564?
  • Ivano Di Meo, Chiara Cavestro, Silvia Pedretti, Tingting Fu, Simona Ligorio, et al.. Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model. International Journal of Molecular Sciences, 2020, 21 (24), pp.9707. ?10.3390/ijms21249707?. ?hal-03116877?
  • Tingting Fu, Janina Oetjen, Manuel Chapelle, Alexandre Verdu, Matthias Szesny, et al.. In situ isobaric lipid mapping by MALDI-ion mobility separation-mass spectrometry imaging. Journal of Mass Spectrometry, 2020, 55 (9), pp.e4531. ?10.1002/jms.4531?. ?hal-03113280?
  • Julien Faugère, Duarte Gouveia, Sophie Ayciriex, Arnaud Chaumot, Christine Almunia, et al.. High-multiplexed monitoring of protein biomarkers in the sentinel Gammarus fossarum by targeted scout-MRM assay, a new vision for ecotoxicoproteomics. Journal of Proteomics, 2020, 226, pp.103901. ?10.1016/j.jprot.2020.103901?. ?hal-02903090?
  • Maxime Leprêtre, Mélissa Palos-Ladeiro, Julien Faugere, Christine Almunia, Jérôme Lemoine, et al.. From shotgun to targeted proteomics: rapid Scout-MRM assay development for monitoring potential immunomarkers in Dreissena polymorpha. Analytical and Bioanalytical Chemistry, 2020, 412 (26), pp.7333-7347. ?10.1007/s00216-020-02868-2?. ?hal-04460382?
  • Fabrice Saintmont, Julien de Winter, Fabien Chirot, Emilie Halin, Philippe Dugourd, et al.. How Spherical Are Gaseous Low Charged Dendrimer Ions: A Molecular Dynamics/Ion Mobility Study?. Journal of The American Society for Mass Spectrometry, 2020, 31 (8), pp.1673-1683. ?10.1021/jasms.0c00113?. ?hal-02923341?
  • Clothilde Comby-Zerbino, Franck Bertorelle, Philippe Dugourd, Rodolphe Antoine, Fabien Chirot. Structure and Charge Heterogeneity in Isomeric Au25(MBA)18 Nanoclusters—Insights from Ion Mobility and Mass Spectrometry. Journal of Physical Chemistry A, 2020, 124 (28), pp.5840-5848. ?10.1021/acs.jpca.0c03131?. ?hal-02919814?
  • Arnaud Salvador, Romain Carrière, Sophie Ayciriex, Christelle Margoum, Yves Leblanc, et al.. Scout-multiple reaction monitoring: A liquid chromatography tandem mass spectrometry approach for multi-residue pesticide analysis without time scheduling. Journal of Chromatography A, 2020, 1621, pp.461046. ?10.1016/j.chroma.2020.461046?. ?hal-02771252?
  • Salomé Poyer, Chang Min Choi, Claire Deo, Nicolas Bogliotti, Juan Xie, et al.. Kinetic study of azobenzene E/Z isomerization using ion mobility-mass spectrometry and liquid chromatography-UV detection. Analyst, 2020, 145, pp.4012-4020. ?10.1039/D0AN00048E?. ?hal-02550455?
  • Maxime Leprêtre, Christine Almunia, J. Armengaud, Antoine Le Guernic, Arnaud Salvador, et al.. Identification of immune-related proteins of Dreissena polymorpha hemocytes and plasma involved in host-microbe interactions by differential proteomics. Scientific Reports, 2020, 10 (1), pp.6226. ?10.1038/s41598-020-63321-z?. ?hal-02608535?
  • Sophie Ayciriex, Romain Carrière, Chloé Bardet, Yves J. C. Le Blanc, Arnaud Salvador, et al.. Streamlined Development of Targeted Mass Spectrometry‐Based Method Combining Scout‐MRM and a Web‐Based Tool Indexed with Scout Peptides. Proteomics, 2020, pp.1900254. ?10.1002/pmic.201900254?. ?hal-02436928?
  • Damien Fournier, Romain Carrière, Maxime Bour, Emilie Grisot, Pauline Triponney, et al.. Mechanisms of Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa : Results of the GERPA Multicenter Study. Antimicrobial Agents and Chemotherapy, 2020, ?10.1128/AAC.01117-20?. ?hal-03028399?
  • Mathilde Bouakil, Fabien Chirot, Marion Girod, P. Dugourd, L. Macaleese. Secondary structure effects on internal proton transfer in poly-peptides. Structural Dynamics, 2020, 7 (2), pp.024302. ?10.1063/4.0000003?. ?hal-02532742?
  • Mathieu Lalande, Lucas Schwob, Violaine Vizcaino, Fabien Chirot, Philippe Dugourd, et al.. Direct Radiation Effects on the Structure and Stability of Collagen and Other Proteins. ChemBioChem, 2019, 20, pp.1-10. ?10.1002/cbic.201900202?. ?hal-02295917?
  • Maxime Lepretre, Christine Almunia, J. Armengaud, Arnaud Salvador, Alain Geffard, et al.. The immune system of the freshwater zebra mussel, Dreissena polymorpha, decrypted by proteogenomics of hemocytes and plasma compartments. Journal of Proteomics, 2019, 202, pp.103366. ?10.1016/j.jprot.2019.04.016?. ?hal-02108964?
  • Duarte Gouveia, Christine Almunia, Yannick Cogne, Olivier Pible, Davide Degli Esposti, et al.. Ecotoxicoproteomics: A decade of progress in our understanding of anthropogenic impact on the environment. Journal of Proteomics, 2019, 198, pp.66-77. ?10.1016/j.jprot.2018.12.001?. ?hal-02109172?
  • Marion Girod. Increasing specificity of tandem mass spectrometry by laser‐induced dissociation. Rapid Communications in Mass Spectrometry, 2019, Perspectives on the future of Mass Spectrometry, 33 (S3), pp.64-71. ?10.1002/rcm.8148?. ?hal-02389133?
  • Franck Bertorelle, Isabelle Russier-Antoine, Clothilde Comby-Zerbino, Fabien Chirot, Philippe Dugourd, et al.. Isomeric Effect of Mercaptobenzoic Acids on the Synthesis, Stability, and Optical Properties of Au 25 (MBA) 18 Nanoclusters. ACS Omega, 2018, 3 (11), pp.15635-15642. ?10.1021/acsomega.8b02615?. ?hal-02108463?
  • Mathieu Lalande, Clothilde Comby-Zerbino, Mathilde Bouakil, Philippe Dugourd, Fabien Chirot, et al.. Isolated Collagen Mimetic Peptide Assemblies Have Stable Triple-Helix Structures. Chemistry - A European Journal, 2018, 24 (52), pp.13728 - 13733. ?10.1002/chem.201802929?. ?hal-01900222?
  • Luke Macaleese, Marion Girod, Laurent Nahon, Alexandre Giuliani, Rodolphe Antoine, et al.. Radical Anions of Oxidized vs. Reduced Oxytocin: Influence of Disulfide Bridges on CID and Vacuum UV Photo-Fragmentation. Journal of The American Society for Mass Spectrometry, 2018, 29 (9), pp.1826-1834. ?10.1007/s13361-018-1989-8?. ?hal-01864504?
  • Clothilde Comby-Zerbino, Franck Bertorelle, Fabien Chirot, Philippe Dugourd, Rodolphe Antoine. Structural insights into glutathione-protected gold Au10−12(SG)10−12 nanoclusters revealed by ion mobility mass spectrometry. The European Physical Journal D : Atomic, molecular, optical and plasma physics, 2018, 72 (8), pp.Article Number: 144. ?10.1140/epjd/e2018-90133-8?. ?hal-01900250?
  • Aurore Charnot, Duarte Gouveia, Sophie Ayciriex, Jérôme Lemoine, J. Armengaud, et al.. On-Line Solid Phase Extraction Liquid Chromatography-Mass Spectrometry Method for Multiplexed Proteins Quantitation in an Ecotoxicology Test Specie: Gammarus fossarum. Journal of Applied Bioanalysis, 2018, 4 (3), pp.81-101. ?10.17145/jab.18.012?. ?hal-01860702?
  • Lény Garcia, Marion Girod, Magali Rompais, Philippe Dugourd, Christine Carapito, et al.. Data-Independent Acquisition Coupled to Visible Laser-Induced Dissociation at 473 nm (DIA-LID) for Peptide-Centric Specific Analysis of Cysteine-Containing Peptide Subset. Analytical Chemistry, 2018, 90 (6), pp.3928 - 3935. ?10.1021/acs.analchem.7b04821?. ?hal-01767310?
  • Tiphaine Cecchini, Eun-Jeong Yoon, Yannick Charretier, Chloé Bardet, Corinne Beaulieu, et al.. Deciphering Multifactorial Resistance Phenotypes in Acinetobacter baumannii by Genomics and Targeted Label-free Proteomics. Molecular and Cellular Proteomics, 2018, 17 (3), pp.442 - 456. ?10.1074/mcp.RA117.000107?. ?hal-01767739?
  • Jean Haler, Philippe Massonnet, Fabien Chirot, Christopher Kune, Clothilde Comby-Zerbino, et al.. Comparison of Different Ion Mobility Setups Using Poly (Ethylene Oxide) PEO Polymers: Drift Tube, TIMS, and T-Wave. Journal of The American Society for Mass Spectrometry, 2018, 29 (1), pp.114-120. ?10.1007/s13361-017-1822-9?. ?hal-01704016?
  • Mohammad Halim, Luke Macaleese, Jérôme Lemoine, Rodolphe Antoine, Philippe Dugourd, et al.. Ultraviolet, Infrared, and High-Low Energy Photodissociation of Post-Translationally Modified Peptides. Journal of The American Society for Mass Spectrometry, 2018, 29 (2), pp.270 - 283. ?10.1007/s13361-017-1794-9?. ?hal-01767664?
  • Steven Daly, Luke Macaleese, Philippe Dugourd, Fabien Chirot. Combining Structural Probes in the Gas Phase - Ion Mobility-Resolved Action-FRET. Journal of The American Society for Mass Spectrometry, 2018, 29 (1), pp.133-139. ?10.1007/s13361-017-1824-7?. ?hal-01704152?
  • Chang Min Choi, Luke Macaleese, Philippe Dugourd, Myoung Choul Choi, Fabien Chirot. Photo-induced linkage isomerization in the gas phase probed by tandem ion mobility and laser spectroscopy. Physical Chemistry Chemical Physics, 2018, 20 (17), pp.12223-12228. ?10.1039/c8cp01833b?. ?hal-01859155?
  • Antonin Soleilhac, Franck Bertorelle, Clothilde Comby-Zerbino, Fabien Chirot, Nathalie Calin, et al.. Size Characterization of Glutathione-Protected Gold Nanoclusters in the Solid, Liquid and Gas Phases. Journal of Physical Chemistry C, 2017, 121 (49), pp.27733 - 27740. ?10.1021/acs.jpcc.7b09500?. ?hal-01679519?
  • Duarte Gouveia, Arnaud Chaumot, Aurore Charnot, Christine Almunia, Adeline François, et al.. Ecotoxico-Proteomics for Aquatic Environmental Monitoring: First in Situ Application of a New Proteomics-Based Multibiomarker Assay Using Caged Amphipods. Environmental Science and Technology, 2017, 51 (22), pp.13417-13426. ?10.1021/acs.est.7b03736?. ?hal-01663631?
  • Quentin Duez, Fabien Chirot, Romain Liénard, Thomas Josse, Chang Min Choi, et al.. Polymers for Traveling Wave Ion Mobility Spectrometry Calibration. Journal of The American Society for Mass Spectrometry, 2017, 28 (11), pp.2483-2491. ?10.1007/s13361-017-1762-4?. ?hal-01608986?
  • Piia Liigand, Agnes Heering, Karl Kaupmees, Ivo Leito, Marion Girod, et al.. The Evolution of Electrospray Generated Droplets is Not Affected by Ionization Mode. Journal of The American Society for Mass Spectrometry, 2017, 28 (10), pp.2124 - 2131. ?10.1007/s13361-017-1737-5?. ?hal-01598111?
  • D. Gouveia, Arnaud Chaumot, A. Charnot, H. Quéau, J. Armengaud, et al.. Assessing the relevance of a multiplexed methodology for proteomic biomarker measurement in the invertebrate species Gammarus fossarum : A physiological and ecotoxicological study. Aquatic Toxicology, 2017, 190, pp.199 - 209. ?10.1016/j.aquatox.2017.07.007?. ?hal-01682339?
  • Antonin Soleilhac, Franck Bertorelle, Philippe Dugourd, Marion Girod, Rodolphe Antoine. Monitoring methanol-induced protein unfolding by fluorescence anisotropy measurements of covalently labelled rhodamine probe. The European Physical Journal D : Atomic, molecular, optical and plasma physics, 2017, 71 (6), ?10.1140/epjd/e2017-70760-3?. ?hal-01569441?
  • Aurore Charnot, Duarte Gouveia, J. Armengaud, Christine Almunia, Arnaud Chaumot, et al.. Multiplexed assay for protein quantitation in the invertebrate Gammarus fossarum by liquid chromatography coupled to tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 2017, 409 (16), pp.3969-3991. ?10.1007/s00216-017-0348-0?. ?hal-01539762?
  • Piia Liigand, Karl Kaupmees, Kristjan Haav, Jaanus Liigand, Ivo Leito, et al.. Think Negative: Finding the Best Electrospray Ionization/MS Mode for Your Analyte. Analytical Chemistry, 2017, 89 (11), pp.5665-5668. ?10.1021/acs.analchem.7b00096?. ?hal-01546359?
  • Steven Daly, Chang Min Choi, Athanasios Zavras, Marjan Krstic, Fabien Chirot, et al.. Gas-Phase Structural and Optical Properties of Homo- and Heterobimetallic Rhombic Dodecahedral Nanoclusters [Ag 14? n Cu n (C?C t Bu) 12 X] + (X = Cl and Br): Ion Mobility, VUV and UV Spectroscopy, and DFT Calculations. Journal of Physical Chemistry C, 2017, 121 (20), pp.10719 - 10727. ?10.1021/acs.jpcc.7b02663?. ?hal-01544767?
  • Steven Daly, Chang Min Choi, Fabien Chirot, Luke Macaleese, Rodolphe Antoine, et al.. Action-Self Quenching: Dimer-Induced Fluorescence Quenching of Chromophores as a Probe for Biomolecular Structure. Analytical Chemistry, 2017, 89 (8), pp.4604-4610. ?10.1021/acs.analchem.7b00152?. ?hal-01539953?
  • Q Duez, T. Josse, Vincent Lemaur, Fabien Chirot, Chang Min Choi, et al.. Correlation between the shape of the ion mobility signals and the stepwise folding process of polylactide ions. Journal of Mass Spectrometry, 2017, 52 (3), pp.133-138. ?10.1002/jms.3915?. ?hal-01518997?
  • Blandine Rougemont, Sebastien B Gallo, Sophie Ayciriex, Romain Carrière, Hubert Hondermarck, et al.. Scout-MRM: Multiplexed Targeted Mass Spectrometry-Based Assay without Retention Time Scheduling Exemplified by Dickeya dadantii Proteomic Analysis during Plant Infection. Analytical Chemistry, 2017, 89 (3), pp.1421-1426 ?10.1021/acs.analchem.6b03201?. ?hal-01518912?
  • Steven Daly, Geoffrey Knight, Mohamed Abdul Halim, Alexander Kulesza, Chang Min Choi, et al.. Action-FRET of a Gaseous Protein. Journal of The American Society for Mass Spectrometry, 2017, 28 (1), pp.38 - 49. ?10.1007/s13361-016-1449-2?. ?hal-01682690?
  • Lény Garcia, Jérôme Lemoine, Philippe Dugourd, Marion Girod. Fragmentation patterns of chromophore-tagged peptides in visible laser induced dissociation. Rapid Communications in Mass Spectrometry, 2017, 31 (23), pp.1985-1992. ?10.1002/rcm.7984?. ?hal-01646160?
  • Izabella Czerwinska, Alexander Kulesza, Chang Min Choi, Fabien Chirot, Anne-Laure Simon, et al.. Supramolecular influence on cis-trans isomerization probed by ion mobility spectrometry.. Physical Chemistry Chemical Physics, 2016, 18 (47), pp.32331-32336. ?10.1039/C6CP06168K?. ?hal-01546592?
  • Alexandra Gaubert, Jéremy Jeudy, Blandine Rougemont, Claire Bordes, Jérôme Lemoine, et al.. Identification and absolute quantification of enzymes in laundry detergents by liquid chromatography tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 2016, 408 (17), pp.4669-4681. ?10.1007/s00216-016-9550-8?. ?hal-01356216?
  • Steven Daly, Marion Girod, Marin Vojkovic, Alexandre Giuliani, Rodolphe Antoine, et al.. Single-Photon, Double Photodetachment of Nickel Phthalocyanine Tetrasulfonic Acid 4-Anions. Journal of Physical Chemistry Letters, 2016, 7 (13), pp.2586-2590. ?10.1021/acs.jpclett.6b01030?. ?hal-01344589?
  • Athanasios Zavras, George N. Khairallah, Marjan Krstić, Marion Girod, Steven Daly, et al.. Ligand-induced substrate steering and reshaping of [Ag-2(H)](+) scaffold for selective CO2 extrusion from formic acid. Nature Communications, 2016, 7, pp.Article Number: 11746. ?10.1038/ncomms11746?. ?hal-01356285?
  • Antonin Soleilhac, Marion Girod, Philippe Dugourd, Béatrice Burdin, Julien Parvole, et al.. Temperature Response of Rhodamine B-Doped Latex Particles. From Solution to Single Particles. Langmuir, 2016, 32 (16), pp.4052-4058. ?10.1021/acs.langmuir.6b00647?. ?hal-01356205?
  • Blandine Rougemont, Catherine Fonbonne, Jérôme Lemoine, Vanessa Bourgeaux, Arnaud Salvador. Liquid chromatography coupled to tandem mass spectrometry for the analysis of inositol hexaphosphate after solid-phase extraction. Journal of Liquid Chromatography and Related Technologies, 2016, 39 (8), pp.408-414. ?10.1080/10826076.2016.1169427?. ?hal-01356192?
  • Valéria Lepère, Katia Le Barbu-Debus, Carine Clavaguera, D. Scuderi, Giovanni Piani, et al.. Chirality-dependent structuration of protonated or sodiated polyphenylalanines: IRMPD and ion mobility studies. Physical Chemistry Chemical Physics, 2016, 18 (3), pp.1807-18017. ?10.1039/c5cp06768e?. ?hal-01356198?
  • Steven Daly, Alexander Kulesza, Frederic Poussigue, Anne-Laure Simon, Chang Min Choi, et al.. Conformational changes in amyloid-beta (12-28) alloforms studied using action-FRET, IMS and molecular dynamics simulations (vol 6, pg 5040, 2015). Chemical Science, 2016, 7, pp.1609-1610. ?10.1039/c5sc90069g?. ?hal-02303924?
  • Chang Min Choi, Anne-Laure Simon, Fabien Chirot, Alexander Kulesza, Geoffrey Knight, et al.. Charge, Color, and Conformation: Spectroscopy on Isomer-Selected Peptide Ions. Journal of Physical Chemistry B, 2016, 120 (4), pp.709-714. ?10.1021/acs.jpcb.5b11919?. ?hal-01345016?
  • Mohammad A Halim, Marion Girod, Luke Macaleese, Jérôme Lemoine, Rodolphe Antoine, et al.. Combined Infrared Multiphoton Dissociation with Ultraviolet Photodissociation for Ubiquitin Characterization. Journal of The American Society for Mass Spectrometry, 2016, 27 (9), pp.1435-1442. ?10.1007/s13361-016-1419-8?. ?hal-01344631?
  • Jaanus Liigand, Anneli Kruve, Piia Liigand, Asko Laaniste, Marion Girod, et al.. Transferability of the electrospray ionization efficiency scale between different instruments. Journal of The American Society for Mass Spectrometry, 2015, 26 (11), pp.1923-1930. ?10.1007/s13361-015-1219-6?. ?hal-01229075?
  • Blandine Rougemont, Romain Simon, Romain Carrière, Jordane Biarc, Catherine Fonbonne, et al.. Absolute quantification of dengue virus serotype 4 chimera vaccine candidate in Vero cell culture by targeted mass spectrometry. Proteomics, 2015, 15 (19), pp.3320-3330. ?10.1002/pmic.201500101?. ?hal-01229336?
  • Kévin Jeanne Dit Fouque, Hélène Lavanant, Séverine Zirah, Jérôme Lemoine, Sylvie Rebuffat, et al.. Gas-phase conformations of capistruin - comparison of lasso, branched-cyclic and linear topologies. Rapid Communications in Mass Spectrometry, 2015, 29 (15), pp.1411-1419. ?10.1002/rcm.7231?. ?hal-01186671?
  • Jordane Biarc, Romain Simon, Catherine Fonbonne, Jean-François Léonard, Jean-Charles Gauthier, et al.. Absolute quantification of podocalyxin, a potential biomarker of glomerular injury in human urine, by liquid chromatography-mass spectrometry. Journal of Chromatography A, 2015, 1397, pp.81-85. ?10.1016/j.chroma.2015.04.003?. ?hal-01164871?
  • Marion Girod, Zeljka Sanader, Marin Vojkovic, Rodolphe Antoine, Luke Macaleese, et al.. UV Photo-dissociation of proline-containing peptide ions: Insights from molecular dynamics. Journal of The American Society for Mass Spectrometry, 2015, 26 (3), pp.432-443. ?10.1007/s13361-014-1038-1?. ?hal-01345987?
  • Steven Daly, Alexander Kulesza, F Poussigue, Anne-Laure Simon, Chang Min Choi, et al.. Conformational changes in Amyloid-Beta (12-28) alloforms studied using action-FRET, IMS and molecular dynamics simulations. Chemical Science, 2015, 6 (8), pp.5040-5047. ?10.1039/C5SC01463H?. ?hal-01344545?
  • Yannick Charretier, Olivier Dauwalder, Christine Franceschi, Elodie Degout-Charmette, Gilles Zambardi, et al.. Rapid bacterial identification, resistance, virulence and type profiling using selected reaction monitoring mass spectrometry. Scientific Reports, 2015, 5, pp.13944. ?10.1038/srep13944?. ?hal-01229864?
  • Antonin Soleilhac, Xavier Dagany, Philippe Dugourd, Marion Girod, Rodolphe Antoine. Correlating droplet size with temperature changes in electrospray source by optical methods.. Analytical Chemistry, 2015, 87 (16), pp.8210-8217. ?10.1021/acs.analchem.5b00976?. ?hal-01344760?
  • Anne-Laure Simon, Fabien Chirot, Chang Min Choi, Christian Clavier, Marc Barbaire, et al.. Tandem ion mobility spectrometry coupled to laser excitation. Review of Scientific Instruments, 2015, 86 (9), pp.Article Number: 094101. ?10.1063/1.4930604?. ?hal-01344740?
  • Rodolphe Antoine, Jérôme Lemoine, Philippe Dugourd. Electron photodetachment dissociation for structural characterization of synthetic and bio-polymer anions. Mass Spectrometry Reviews, 2014, 33 (6), pp.501-522. ?10.1002/mas.21402?. ?hal-00954983?
  • Marion Girod, Marjan Krstić, Rodolphe Antoine, Luke Macaleese, Jérôme Lemoine, et al.. Formation and characterisation of the silver hydride nanocluster cation [Ag3H2((Ph2P)(2)CH2)](+) and its release of hydrogen. Chemistry - A European Journal, 2014, 20 (50), pp.16626-16633. ?10.1002/chem.201404110?. ?hal-01230129?
  • Judith Trapp, J. Armengaud, Arnaud Salvador, Arnaud Chaumot, Olivier Geffard. Next-generation proteomics: toward customized biomarkers for environmental biomonitoring. Environmental Science and Technology, 2014, 48 (23), pp.13560-13572. ?10.1021/es501673s?. ?hal-01230133?
  • Jaanus Liigand, Anneli Kruve, Ivo Leito, Marion Girod, Rodolphe Antoine. Effect of mobile phase on electrospray ionization efficiency. Journal of The American Society for Mass Spectrometry, 2014, 25 (11), pp.1853-1861. ?10.1007/s13361-014-0969-x?. ?hal-01230362?
  • Jordane Biarc, Philippe Gonzalo, Ivan Mikaelian, Laurent Fattet, Mathieu Deygas, et al.. Combination of a discovery LC-MS/MS analysis and a label-free quantification for the characterization of an epithelial-mesenchymal transition signature. Journal of Proteomics, 2014, 110, pp.183-194. ?10.1016/j.jprot.2014.05.026?. ?hal-01230272?
  • Alexander Chramow, Tanam S Hamid, Livia S Eberlin, Marion Girod, Demian R Ifa. Imaging of whole zebra fish (Danio rerio) by desorption electrospray ionization mass spectrometry.. Rapid Communications in Mass Spectrometry, 2014, 28 (19), pp.2084-2088. ?10.1002/rcm.6993?. ?hal-01070832?
  • Romain Simon, Sébastien Passeron, Jérôme Lemoine, Arnaud Salvador. Hydrophilic interaction liquid chromatography as second dimension in multidimensional chromatography with an anionic trapping strategy: application to prostate-specific antigen quantification.. Journal of Chromatography A, 2014, 1354, pp.75-84. ?10.1016/j.chroma.2014.05.063?. ?hal-01071821?
  • Romain Simon, Jérôme Lemoine, Catherine Fonbonne, Aurore Jaffuel, Jean-François Léonard, et al.. Absolute quantification of podocin, a potential biomarker of glomerular injury in human urine, by liquid chromatography-multiple reaction monitoring cubed mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2014, 94, pp.84-91. ?10.1016/j.jpba.2014.01.019?. ?hal-00954969?
  • Quentin Enjalbert, Marion Girod, Jérémy Jeudy, Jordane Biarc, Romain Simon, et al.. Combined collision-induced dissociation and photo-selected reaction monitoring mass spectrometry modes for simultaneous analysis of coagulation factors and estrogens. Journal of Pharmaceutical Analysis, 2014, 4 (3), pp.183-189. ?10.1016/j.jpha.2013.09.004?. ?hal-01356364?
  • Yuefei Ji, Corinne Ferronato, Arnaud Salvador, Xi Yang, Jean-Marc Chovelon. Degradation of ciprofloxacin and sulfamethoxazole by ferrous-activated persulfate: implications for remediation of groundwater contaminated by antibiotics.. Science of the Total Environment, 2014, 472, pp.800-808. ?10.1016/j.scitotenv.2013.11.008?. ?hal-00967478?
  • Jéremy Jeudy, Arnaud Salvador, Romain Simon, Aurore Jaffuel, Catherine Fonbonne, et al.. Overcoming biofluid protein complexity during targeted mass spectrometry detection and quantification of protein biomarkers by MRM cubed (MRM3). Analytical and Bioanalytical Chemistry, 2014, 406 (4), pp.1193-1200. ?10.1007/s00216-013-7266-6?. ?hal-00954963?
  • David Ropartz, Jérôme Lemoine, Alexandre A. Giuliani, Yann Bittebiere, Quentin Enjalbert, et al.. Deciphering the structure of isomeric oligosaccharides in a complex mixture by tandem mass spectrometry: photon activation with vacuum ultra-violet brings unique information and enables definitive structure assignment.. Analytica Chimica Acta, 2014, 807, pp.84-95. ?10.1016/j.aca.2013.11.018?. ?hal-00954660?
  • R. Hazime, Q. H. Nguyen, Corinne Ferronato, Arnaud Salvador, F. Jaber, et al.. Comparative study of imazalil degradation in three systems: UV/TiO2, UV/K2S2O8 and UV/TiO2/K2S2O8. Applied Catalysis B: Environmental, 2014, 144, pp.286-291. ?10.1016/j.apcatb.2013.07.001?. ?hal-00905725?
  • Matthias Vonderach, Marc-Oliver Winghart, Luke Macaleese, Fabien Chirot, Rodolphe Antoine, et al.. Conformer-selective photoelectron spectroscopy of alpha-lactalbumin derived multianions in the gas phase. Physical Chemistry Chemical Physics, 2014, 16 (7), pp.3007-3013. ?10.1039/c3cp54596b?. ?hal-00954595?
  • Marion Girod, Jordane Biarc, Quentin Enjalbert, Arnaud Salvador, Rodolphe Antoine, et al.. Implementing visible 473 nm photodissociation in a Q-Exactive mass spectrometer: towards specific detection of cysteine-containing peptides. Analyst, 2014, 139 (21), pp.5523-5530. ?10.1039/C4AN00956H?. ?hal-01345989?
  • Marion Girod, Quentin Enjalbert, Claire Brunet, Rodolphe Antoine, Jérôme Lemoine, et al.. Structural basis of protein oxidation resistance: a lysozyme study.. PLoS ONE, 2014, 9 (7), pp.e101642. ?10.1371/journal.pone.0101642?. ?hal-01071810?
  • Fabien Chirot, Jérôme Lemoine, Luke Mac Aleese, Philippe Dugourd. Spectrométrie par mobilité ionique et agrégation des protéines. Spectra Analyse, 2012, 285, pp.64. ?hal-00963599?