Micro & Nanobiotechnologies

Dans les domaines des nanobiosciences, des micronanotechnologies, du génie électrique et de la physique appliquée, le groupe développe des biocapteurs et des micronanotechnologies non conventionnelles pour créer des outils analytiques flexibles basés sur des puces BioLab-on-chips, des micro/nanocapteurs, micromélangeurs/microfiltres en utilisant également des nanoparticules. Ces outils novateurs, conçus pour être adaptés à une production à grande échelle à faible coût, ont des applications dans le domaine de la Santé allant de la découverte et le diagnostic puis le suivi de maladies en s’intéressant notammant aux biomarqueurs du cancer.
D’autres développements sont également réalisés dans le domaine des analyses environnementales.

Axes de recherche

Nous développons des biocapteurs basés sur des surfaces spécialement conçues en utilisant l’impression par micro-contact (µCP) et le dépôt électro-sans (EDL). Nous concevons également Biolab-on-chips avec des microélectrodes en or fabriquées sur des substrats (p. ex., polyimide) par une combinaison d’outils de lithographie souple tels que le moulage de répliques, µCP, et les monocouches auto-assemblées (SAMs). D’autres microfiltres et micromélangeurs flexibles sont basés sur l’étanchéité du poly(diméthylsiloxane) microstructuré (PDMS) aux différents films thermoplastiques fonctionnalisés (polyimide (PI), naphthalate de polyéthylène (PEN) et polyéthylène téréphtalate (PET).

Aujourd’hui, nous visons également à mettre au point de nouvelles méthodes de production de masse de transistors à effet nanométrique (NanoFETs) à base de nanofils polypyrrole (NPpyFET) à faible coût à l’aide de techniques de nanofabrication « non conventionnelles » (p. ex., EDL, impression en nanocontact submergé, etc.). Nous nous attaquons à l’optimisation de ces NPpyFET pour la détection des biomarqueurs du cancer, en particulier l’antigène prostatique spécifique (PSA).

Nos travaux sont également basés sur l’élaboration de nanoparticules. Notre recherche combine plusieurs aspects: la polymérisation en milieu dispersé pour l’élaboration de particules fonctionnalisées pour le diagnostic in-vitro et l’analyse environnementale, l’encapsulation de molécules actives pour la thérapeutique, l’encapsulation d’agents de contrastes pour le diagnostic in-vivo et enfin l’encapsulation de molécules pour la théranostique et la cosmétique. Pour rendre notre recherche compétitive et applicable, nous souhaitons faire évoluer notre activité du fondamental à une finalité appliquée via le contact direct avec les médecins par exemple ou les sociétés concernées pour répondre à des problématiques réelles et par conséquent à un besoin.

Projets de recherche

PROJETS ACTUELS

Projet R&D Booster/RESOL (2021-2023)

(https://polyloop.fr/projet-resol-enfin-du-pvc-recycle-pour-les-enducteurs/)

Objectif: Trouver une solution pour obtenir un PVC recyclé qui soit réutilisable dans des procédés d’enduction plastisol suite au processus de recyclage. Pour ce faire, l’aide allouée par le R&D Booster va permettre de construire un démonstrateur sous la forme d’un pilote de taille intermédiaire pouvant traiter 5 kg de déchets et permettant de vérifier la viabilité technique pour incorporer du r-PVC dans le procédé plastisol pour les domaines du vêtement de protection et du bâtiment.

Projet financé par la Région Auvergne-Rhône-Alpes dans le cadre de l’appel à projets R&D Booster

Porteur : Polyloop

Partenaires : Chomarat, ISA, LAGEPP

Projet BioNanoSens (2020-2024)

( https://www.bionanosens.eu/  – https://cordis.europa.eu/project/id/951887 )

Objectif : Le projet BIONANOSENS, financé par l’Union Européenne et axé sur le développement d’une nouvelle électronique biomoléculaire pour la bionanotechnologie analytique, jumelle l’IMBG ( Institut de Biologie Moléculaire et de Génétique, Ukraine) avec des partenaires de l’UE afin de renforcer les capacités de cet Institut et de créer un Centre d’excellence de renommée internationale dans le domaine des biotechnologies analytiques. Les scientifiques de classe mondiale de l’Institut bénéficieront également de ce jumelage dans des domaines allant de la rédaction de propositions et de la gestion de subventions à la mise en réseau et au mentorat de jeunes scientifiques, complétant ainsi l’expertise scientifique actuelle avec les compétences nécessaires pour assurer l’afflux de fonds de recherche et de nouveaux talents.

Porteur : IMBG, Ukraine

Partenaires : UCBL 1 (ISA, IRCELYON), Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Zentrum für Soziale Innovation (ZSI), Vienne ; Lyon Ingénieurie Projet (LIP)

https://www.bionanosens.eu/news/bionanosens-training-workshop-22nd-and-23rd-of-november-2023.html

 

PROJETS PASSÉS

Projet ADEME/ECLA (2018-2022)

(https://www.vegepolys-valley.eu/les-projets/les-projets-des-membres/8974-ecla.html)

 

Projet Européen H2020 KARDIATOOL ( 2017 – 2021)

(https://cordis.europa.eu/project/id/768686/fr – http://www.kardiatool.eu/ )

Objectif: Le projet KardiaTool, financé par l’UE, ambitionne de mettre au point un appareil portable capable de diagnostiquer l’insuffisance cardiaque et de surveiller le traitement sur le lieu de soins à partir d’échantillons de salive. Le dispositif intégrera différents biomarqueurs de l’insuffisance cardiaque à partir de la salive, proposant une alternative économique au dépistage sanguin. La facilité d’utilisation et le potentiel de surveillance continue que propose la solution KardiaTool devraient améliorer la pratique clinique et les soins prodigués aux patients souffrant d’insuffisance cardiaque.

Porteur du projet : UCBL, ISA

Partenaires du projet : FORTH, CSIC, UNIPI, FRAUNHOFER Erlangen, BIOTRAY, MICRONIT, IMEC, UOI, VALOTEC, CNR, ENACHIP, UNISU, UCD

Partenariats

Partenariats industriels

Collaborations Scientifiques

School of Integrated Science and Innovation, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Pathum Thani 12121, Thailand

Center for Research Innovation and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700 Thailand

Capacités expérimentales et instrumentales

Equipements de conception/fabrication/ nano-adressage

Machines de Câblage   

Ibond 5000 Wegde (MPP)

Lithographie par nanoimpression
Lithographie douce

Impression par micro-contact

Equipements de caractérisations / mesures de surfaces

Microscope à Force Atomique (AFM)
Microscope Electronique à Balayage équipé d’une sonde à dispersion d’Energie (SEM-EDS)
Microscope de fluorescence
Equipements de mesures électrochimiques (potentiostat)

La plateforme “Analyse Thermique – Gaz – COV” fait partie intégrante de l’équipe de recherche “Micro et Nanobiotechnologies”. Elle dispose de différentes instrumentations dans les domaines de : l’analyse thermique, l’analyse de gaz et COVs, la chromatographie d’exclusion stérique.

https://www.isa-lyon.fr/facility/thermiques/

Personnels

  • Chercheurs et enseignants-chercheurs

    • Abdelhamid ELAISSARI
    • Abdelhamid ERRACHID EL SALHI
    • Monique SIGAUD
    • Nadia ZINE
  • Soutien à la recherche

    • Marie HANGOUET
    • Guy RAFFIN
    • Pierrick ZERBINO
  • Post-doctorants

    • Zouhair AIT TOUCHENTE
  • Doctorants

    • Oluwatoyin AINA
    • Noor ALRUSHAID
    • Eslam ELKALLA
    • Eva HOBEIKA
    • Léony SOARES DE OLIVEIRA
    • Patcharapan SUWANNIN
  • Autres

    • JAVIER CABELLO PASTOR
    • Maria CACERES QUESADA
    • Yosra CHRIGUI
    • Jirawan JINDAKAEW
    • Sumera KHIZAR
    • Isaac Aaron MORALES FRIAS
    • Clément PINORINI
    • Léony SOARES DE OLIVEIRA
    • Mongkol TECHAKASIKORNPANICH
    • Guillaume TOURNIER

Publications (sources HAL)

Articles dans une revue

  • Die Chen, Yutao He, Ya Wang, Ziyi Zhang, Yifei Pei, et al.. An immune sandwich electrochemical biosensor based on triple-modified zirconium derivatives for detection of CD146 in serum. Colloids and Surfaces B: Biointerfaces, 2024, 239, pp.113902. ?10.1016/j.colsurfb.2024.113902?. ?hal-04541152?
  • Hamdi Ben Halima, Anis Madaci, Emmanuel Contal, Abdelhamid Errachid-El-Salhi, Boris Lakard, et al.. Conductometric Sensor Based on Electropolymerized Pyrrole-Tailed Ionic Liquids for Acetone Detection. ACS Applied Polymer Materials, 2024, 6 (8), pp.4718-4729. ?10.1021/acsapm.4c00295?. ?hal-04552412?
  • Haifa Mliki, Ahlem Rouis, Mosaab Echabaane, Laura Ceron, Nathalie Perol, et al.. A highly sensitive and selective impedimetric sensor for the determination of oxytetracycline based on a new polyamine functionalized calix [4] arene. Microchemical Journal, 2024, 199, pp.109957. ?10.1016/j.microc.2024.109957?. ?hal-04494091?
  • Zhenzhong Guo, Hanhui Yan, Ruijia Xu, Jingjing Ding, Jing Cheng, et al.. An ultra-sensitive electrochemical biosensor for the detection of procalcitonin in sepsis patients’ serum, using a Cu-BHT-based thin film. Talanta, 2024, 268, pp.125325. ?10.1016/j.talanta.2023.125325?. ?hal-04540433?
  • Zouhair Ait-Touchente, Maya Khellaf, Guy Raffin, Noureddine Lebaz, Abdelhamid Elaissari. Recent advances in polyvinyl chloride (PVC) recycling. Polymers for Advanced Technologies, 2024, 35 (1), ?10.1002/pat.6228?. ?hal-04267777?
  • Ting Li, Dan Shu, Jun Zheng, Die Chen, Jing Cheng, et al.. A sensitive immunosensor for the detection of alkaline phosphatase as a biomarker for fracture healing. Microchemical Journal, 2024, 196, pp.109726. ?10.1016/j.microc.2023.109726?. ?hal-04540456?
  • Hamdi Ben Halima, Nadia Zine, Imad Abrao Nemeir, Norman Pfeiffer, Albert Heuberger, et al.. An ImmunoFET Coupled with an Immunomagnetic Preconcentration Technique for the Sensitive EIS Detection of HF Biomarkers. Micromachines, 2024, 15 (3), pp.296. ?10.3390/mi15030296?. ?hal-04541104?
  • Edward Calzia, Dhekra Ayed, Salwa Ben Aissa, Saber Chatti, Ksenyia Berketa, et al.. A new microconductometric sensor based on a PVC membrane including an o ‐COSAN ion‐pair complex for the detection of caffeine. Electroanalysis, 2024, 36 (4), pp.109957. ?10.1002/elan.202300381?. ?hal-04540606?
  • Marwa Sebai, Asma Hannachi, Nicole Jaffrezic-Renault, Mounir Kanzari. Impedance spectroscopy study of Al/p-Cu2ZnSnS4 thin films Schottky diode grown by a two-stage method. Applied physics. A, Materials science & processing, 2023, 130 (1), pp.40. ?10.1007/s00339-023-07195-8?. ?hal-04541175?
  • Rabiaa Helim, Ali Zazoua, Nicole Jaffrezic-Renault, Hafsa Korri-Youssoufi. Label free electrochemical sensors for Pb(II) detection based on hemicellulose extracted from Opuntia Ficus Indica cactus. Talanta, 2023, 265, pp.124784. ?10.1016/j.talanta.2023.124784?. ?hal-04299636?
  • Jassem Wannassi, Nadhem Missaoui, Chama Mabrouk, Houcine Barhoumi, Robert Crapnell, et al.. Electrochemical Sensors Based on Metal-Organic Framework and Conductive Polymer HKUST-1@PANI for High-Performance Detection of Lead Ions. Journal of The Electrochemical Society, 2023, 170 (11), pp.117504. ?10.1149/1945-7111/ad050c?. ?hal-04540311?
  • Eslam Elkalla, Sumera Khizar, Zouhair Ait-Touchente, Noureddine Lebaz, Marie Hangouët, et al.. Synthesis and characterization of silica-coated oil-in-water (O/W) magnetic emulsion. Emergent Materials, 2023, 6 (6), pp.2027-2039. ?10.1007/s42247-023-00563-3?. ?hal-04252688?
  • Zhiruo Yang, Siying Mao, Lu Wang, Sinan Fu, Yanming Dong, et al.. CRISPR/Cas and Argonaute-Based Biosensors for Pathogen Detection. ACS Sensors, 2023, 8 (10), pp.3623-3642. ?10.1021/acssensors.3c01232?. ?hal-04503750?
  • Yanqu Cai, Die Chen, Yongqi Chen, Ting Li, Lu Wang, et al.. An electrochemical biosensor based on graphene intercalated functionalized black phosphorus/gold nanoparticles nanocomposites for the detection of bacterial enzyme. Microchemical Journal, 2023, 193, pp.109255. ?10.1016/j.microc.2023.109255?. ?hal-04540394?
  • Sinan Fu, Zhizhi Ning, Qiuyue Li, Yutao He, Chang Xie, et al.. Sulfur source-mediated in situ growth of highly conductive nanocomposites for sensitive detection of miRNA-21. Sensors and Actuators B: Chemical, 2023, 392, pp.134086. ?10.1016/j.snb.2023.134086?. ?hal-04497322?
  • Sinan Fu, Chang Xie, Zhiruo Yang, Mingdi Jiang, Jing Cheng, et al.. Electrochemical signal amplification strategy based on trace metal ion modified WS2 for ultra-sensitive detection of miRNA-21. Talanta, 2023, 260 (3), pp.124552. ?10.1016/j.talanta.2023.124552?. ?hal-04497298?
  • Anis Madaci, Hana Ferkous, Amel Sedik, Amel Delimi, Chérifa Boulechfar, et al.. Experimental and theoretical study of polysaccharides extracted from prickly pear nopales Pulp (PPUN) of Opuntia ficus-indica as corrosion inhibitors. Journal of Molecular Liquids, 2023, 384, pp.122272. ?10.1016/j.molliq.2023.122272?. ?hal-04497332?
  • Pouyan Razmshoar, Fatma Besbes, Anis Madaci, Rym Mlika, S. Hajir Bahrami, et al.. A conductometric enzymatic methanol sensor based on polystyrene - PAMAM dendritic polymer electrospun nanofibers. Talanta, 2023, 260, pp.124630. ?10.1016/j.talanta.2023.124630?. ?hal-04497314?
  • Anis Madaci, Patcharapan Suwannin, Guy Raffin, Marie Hangouet, Marie Martin, et al.. A Sensitive Micro Conductometric Ethanol Sensor Based on an Alcohol Dehydrogenase-Gold Nanoparticle Chitosan Composite. Nanomaterials, 2023, 13 (16), pp.2316. ?10.3390/nano13162316?. ?hal-04204911?
  • Manahil Babiker Elamin, Shazalia Mahmoud Ahmed Ali, Amani Chrouda, Laila Alhaidari, Rahaf Mutlaq Alrouqi, et al.. Green synthesis of gum arabic platinum nanoparticle: Electrochemical sensor application for glyphosate detection. Polymers for Advanced Technologies, 2023, 34 (11), pp.3407-3414. ?10.1002/pat.6151?. ?hal-04497525?
  • Sara Atailia, Abdoullatif Baraket, Selma Rabai, Messaoud Benounis, Nicole Jaffrezic, et al.. Electrochemical urea biosensor based on Proteus mirabilis urease immobilized over polyaniline PANi‐Glassy carbon electrode. Electroanalysis, 2023, 35 (9), ?10.1002/elan.202200502?. ?hal-04497305?
  • Ivan Kucherenko, Carole Farre, Gaetan Raimondi, Carole Chaix, Nicole Jaffrezic-Renault, et al.. A novel adenosine triphosphate (ATP) biosensor based on electrospun polymer nanofibers with entrapped hexokinase and glucose oxidase. Applied Nanoscience, 2023, ?10.1007/s13204-023-02861-y?. ?hal-04121224?
  • Michel Rachkidi, Laura Alonso-Sobrado, Guy Raffin, Eric Colinet, Jérôme Randon. Dual detection chromatographic method for fast characterization of nano-gravimetric detector. Talanta, 2023, 257, pp.124359. ?10.1016/j.talanta.2023.124359?. ?hal-04204916?
  • Sabri Ouni, Naim Bel Haj Mohamed, Mohamed Haouari, Abdelhamid Elaissari, Abdelhamid Errachid, et al.. A Novel Green Synthesis of Zinc Sulfide Nano-Adsorbents Using Artemisia Herba Alba Plant Extract for Adsorption and Photocatalysis of Methylene Blue Dye. Chemistry Africa, 2023, 6 (5), pp.2523-2535. ?10.1007/s42250-023-00667-7?. ?hal-04503752?
  • Sabri Ouni, Naim Bel Haj Mohamed, Mohamed Haouari, Abdelhamid Elaissari, Abdelhamid Errachid, et al.. A Novel Green Synthesis of Zinc Sulfide Nano-Adsorbents Using Artemisia Herba Alba Plant Extract for Adsorption and Photocatalysis of Methylene Blue Dye. Chemistry Africa, 2023, 6 (5), pp.2523-2535. ?10.1007/s42250-023-00667-7?. ?hal-04503864?
  • Amani Chrouda, Dhekra Ayed, Manahil Babiker Elamin, Shazalia Mahmoud Ahmed Ali, Laila M Alhaidari, et al.. Design of a Boron-Doped Diamond Microcell Grafted with HRP for the Sensitive and Selective Detection of Ochratoxin A. Chemosensors, 2023, 11, pp.176. ?10.3390/chemosensors11030176?. ?hal-04015127?
  • Essyllt Louarn, Antoinette Boreave, Guy Raffin, Christian George, Philippe Vernoux. Analysis of Unregulated VOCs Downstream a Three-Way Catalyst in a Simulated Gasoline Engine Exhaust under Non-Optimum Conditions. Catalysts, 2023, 13 (3), pp.563. ?10.3390/catal13030563?. ?hal-04037553?
  • Isaac M. Frias, Nadia Zine, Monique Sigaud, Pablo Lozano-Sanchez, Marco Caffio, et al.. Non-covalent π–π functionalized Gii-senseⓇ graphene foam for interleukin 10 impedimetric detection. Biosensors and Bioelectronics, 2023, 222, pp.114954. ?10.1016/j.bios.2022.114954?. ?hal-03997775?
  • Sumera Khizar, Eslam Elkalla, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, et al.. Magnetic nanoparticles: multifunctional tool for cancer therapy. Expert Opinion on Drug Delivery, 2023, 20 (2), pp.189-204. ?10.1080/17425247.2023.2166484?. ?hal-03996447?
  • Sabri Ouni, Anis Madaci, Mohamed Haouari, Naim Bel Haj Mohamed, Francois Bessueille, et al.. A Novel Conductometric Micro-sensor for Methanol Detection Based on Chitosan/Zinc Sulfide-Nanoparticles Composite Obtained by Green Synthesis. Journal of Inorganic and Organometallic Polymers and Materials, 2023, 33 (8), pp.2574-2585. ?10.1007/s10904-023-02696-8?. ?hal-04497317?
  • Olfa Kanoun, Jörg Himmel, Abdelhamid Errachid. Impedance Spectroscopy and Its Application in Measurement and Sensor Technology. Applied Sciences, 2023, 13 (1), pp.244. ?10.3390/app13010244?. ?hal-03997782?
  • Manahil Babiker Elamin, Shazalia Mahmoud Ahmed Ali, Houda Essousi, Amani Chrouda, Laila M Alhaidari, et al.. An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite. Sensors, 2023, 23 (3), pp.1270. ?10.3390/s23031270?. ?hal-03997587?
  • Taha Chabbah, Saber Chatti, Nicole Jaffrezic-Renault, Steffen Weidner, C. Marestin, et al.. Impedimetric sensors based on diethylphosphonate‐containing poly(arylene ether nitrile)s films for the detection of lead ions. Polymers for Advanced Technologies, 2023, 34 (8), pp.2471-2481. ?10.1002/pat.6065?. ?hal-04540521?
  • Hamdi Ben Halima, Abdelhamid Errachid, Nicole Jaffrezic-Renault. Electrochemical Affinity Sensors Using Field Effect Transducer Devices for Chemical Analysis. Electroanalysis, 2023, 35 (1), ?10.1002/elan.202100451?. ?hal-03997051?
  • Sondes Bourigua, Feriel Boussema, Dorsaf Bouaazi, Zeineb Mzoughi, Houcine Barhoumi, et al.. Sensitive electrochemical detection of l-tryptophan using a glassy carbon electrode modified with pectin extracted from Arthrocnemum indicum leaves. Journal of Electroanalytical Chemistry, 2023, 953, pp.117998. ?10.1016/j.jelechem.2023.117998?. ?hal-04540545?
  • Ghenwa Nasr, Hélène Greige-Gerges, Sophie Fourmentin, Abdelhamid Elaissari, Nathalie Khreich. Cyclodextrins permeabilize DPPC liposome membranes: a focus on cholesterol content, cyclodextrin type, and concentration. Beilstein Journal of Organic Chemistry, 2023, 19, pp.1570-1579. ?10.3762/bjoc.19.115?. ?hal-04252977?
  • Hamdi Ben Halima, Abdoullatif Baraket, Clara Vinas, Nadia Zine, Joan Bausells, et al.. Selective Antibody-Free Sensing Membranes for Picogram Tetracycline Detection. Biosensors, 2022, 13 (1), pp.71. ?10.3390/bios13010071?. ?hal-03997564?
  • Kamonchanok Thananukul, Chariya Kaewsaneha, Pakorn Opaprakasit, Nadia Zine, Abdelhamid Elaïssari. Biodegradable porous micro/nanoparticles with thermoresponsive gatekeepers for effective loading and precise delivery of active compounds at the body temperature. Scientific Reports, 2022, 12 (1), pp.10906. ?10.1038/s41598-022-15069-x?. ?hal-03726380?
  • Simona Sawan, Abdelhamid Errachid, Rita Maalouf, Nicole Jaffrezic-Renault. Aptamers functionalized metal and metal oxide nanoparticles: Recent advances in heavy metal monitoring. Trends in Analytical Chemistry, 2022, 157, pp.116748. ?10.1016/j.trac.2022.116748?. ?hal-03997207?
  • Mengtian Deng, Jialu Feng, Dan Tao, Hanhui Yan, Jingjing Ding, et al.. A novel conductive nanocomposite-based biosensor for ultrasensitive detection of microRNA-21 in serum, using methylene blue as mediator. Bioelectrochemistry, 2022, 148, pp.108256. ?10.1016/j.bioelechem.2022.108256?. ?hal-03997413?
  • Pouyan Razmshoar, S. Hajir Bahrami, Mohammad Rabiee, Isaac A.M. Frias, Marie Hangouet, et al.. An impedimetric immunosensor based on PAMAM decorated electrospun polystyrene fibers for detection of interleukin-10 cytokine. Journal of Electroanalytical Chemistry, 2022, 926, pp.116953. ?10.1016/j.jelechem.2022.116953?. ?hal-03996688?
  • Bazla Siddiqui, Asim.Ur. Rehman, Ihsan-Ul Haq, Amal Al-Dossary, Abdelhamid Elaissari, et al.. Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications. International Journal of Pharmaceutics: X, 2022, 4, pp.100116. ?10.1016/j.ijpx.2022.100116?. ?hal-03675389?
  • Ibrahim Musa, Guy Raffin, Marie Hangouet, Marie Martin, Joan Bausells, et al.. Electrospun PVC-nickel phthalocyanine composite nanofiber based conductometric methanol microsensor. Microchemical Journal, 2022, 182, pp.107899. ?10.1016/j.microc.2022.107899?. ?hal-03997245?
  • S V Dzyadevych, O O Soldatkin, V M Arkhypova, L V Shkotova, V M Pyeshkova, et al.. Practical application of electrochemical enzyme biosensors. Biopolymers and Cell, 2022, 38, pp.71 - 92. ?10.7124/bc.000a76?. ?hal-03997502?
  • Amani Chrouda, Dhekra Ayed, Khaoula Zinoubi, Hatem Majdoub, Nicole Jaffrezic-Renault. Highly stable and ultra-sensitive amperometric aptasensor based on pectin stabilized gold nanoparticles on graphene oxide modified GCE for the detection of aflatoxin M1. Food Chemistry Advances, 2022, 1, ?10.1016/j.focha.2022.100068?. ?hal-03997226?
  • Pingping Peng, Sheng Wang, Siyuan Cai, Jing Cheng, Dan Tao, et al.. An ultrasensitive hairpin sensor based on g-C3N4 nanocomposite for the detection of miRNA-155 in breast cancer patient serum. Analytical and Bioanalytical Chemistry, 2022, 414 (24), pp.7325-7334. ?10.1007/s00216-022-04284-0?. ?hal-03997276?
  • Taha Chabbah, Saber Chatti, Fares Zouaoui, Ibtissem Jlalia, Houda Gaiji, et al.. New poly(ether-phosphoramide)s sulfides based on green resources as sensitive films for the specific impedimetric detection of nickel ions. Talanta, 2022, 247, pp.123550. ?10.1016/j.talanta.2022.123550?. ?hal-03769661?
  • Manelle Radjai, Hana Ferkous, Zayneb Jebali, Hatem Majdoub, Riadh Bourzami, et al.. Adsorptive removal of cationic and anionic dyes on a novel mesoporous adsorbent prepared from diatomite and anionic cellulose nanofibrils: Experimental and theoretical investigations. Journal of Molecular Liquids, 2022, 361, pp.119670. ?10.1016/j.molliq.2022.119670?. ?hal-03714148?
  • Zhiyuan Hou, Jun Zheng, Chengfang Zhang, Ting Li, Die Chen, et al.. Direct ultrasensitive electrochemical detection of breast cancer biomarker-miRNA-21 employing an aptasensor based on a microgel nanoparticle composite. Sensors and Actuators B: Chemical, 2022, 367, pp.132067. ?10.1016/j.snb.2022.132067?. ?hal-03997352?
  • Sawsen Azzouzi, Mounir Ben Ali, Francesca Bellagambi, Abdelhamid Elaïssari, Nicole Jaffrezic-Renault, et al.. Spatially hierarchical nano-architecture for real time detection of Interleukin-8 cancer biomarker. Talanta, 2022, 246, pp.123436. ?10.1016/j.talanta.2022.123436?. ?hal-03675524?
  • Meryem Belkilani, Carole Farre, Yves Chevalier, Sylvain Minot, François Bessueille, et al.. Mechanisms of Influenza Virus HA2 Peptide Interaction with Liposomes Studied by Dual-Wavelength MP-SPR. ACS Applied Materials & Interfaces, 2022, ?10.1021/acsami.2c09039?. ?hal-03730479?
  • Ziyu Huang, Yaqi Xu, Ya Cheng, Min Xue, Mengtian Deng, et al.. Recent advances in skin-like wearable sensors: sensor design, health monitoring, and intelligent auxiliary. Sensors & Diagnostics, 2022, 1 (4), pp.686-708. ?10.1039/d2sd00037g?. ?hal-03997435?
  • Fares Zouaoui, Nadia Zine, Abdelhamid Errachid, Nicole Jaffrezic-Renault. Mathematical model and numerical simulation of conductometric biosensor of urea. Electroanalysis, 2022, 34 (7), pp.1131-1140. ?10.1002/elan.202100610?. ?hal-03997063?
  • Zouhour Hsine, Rym Mlika, Nicole Jaffrezic-Renault, Hafsa Korri-Youssoufi. Review—Recent Progress in Graphene Based Modified Electrodes for Electrochemical Detection of Dopamine. Chemosensors, 2022, This article belongs to the Collection Women Special Issue in Chemosensors and Analytical Chemistry, 10 (7), pp.249. ?10.3390/chemosensors10070249?. ?hal-04299825?
  • Wei Liao, Abdelhamid Elaïssari, Sami Ghnimi, Emilie Dumas, Adem Gharsallaoui. Effect of pectin on the properties of nanoemulsions stabilized by sodium caseinate at neutral pH. International Journal of Biological Macromolecules, 2022, 209 (B), pp.1858-1866. ?10.1016/j.ijbiomac.2022.04.160?. ?hal-03702715?
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