Séminaire de Carlos Sorgi, Department of Chemistry, University of São Paulo, Brazil

Dans le cadre de l’animation scientifique, Carlos Sorgi, Professeur Associé en Biochimie au sein du Département de Chimie de l’Université de São Paulo (USP), Brésil, présentera une conférence intitulée “Bioengineering of Lipid Cargo in Extracellular Vesicles: Immunology Function” le mardi 09 septembre à 11h en salle de séminaire.

Résumé de la présentation :
Lipids, and particularly sphingolipids, are central to cellular structure, signaling, and disease mechanisms. Their remarkable structural diversity makes them both biologically significant and analytically challenging. Recent advances in lipidomics, a branch of metabolomics, now allow for comprehensive investigation of lipid profiles in complex biological systems. Using high-resolution liquid chromatography–tandem mass spectrometry (LC-MS/MS), targeted and untargeted approaches have been developed to enhance sensitivity, accuracy, and lipid class coverage. These strategies are crucial not only for profiling lipids in biofluids but also for studying extracellular vesicles (EVs), key mediators of intercellular communication. By integrating optimized pre-analytical extraction methods with powerful MS-based platforms, lipidomics provides unique opportunities to explore lipid cargo and function, involved in immune regulation, and their roles in health and disease. This lecture will highlight our recent methodological advances and applications of lipidomics, getting its potential for biomarker discovery, mechanistic insights, and translational impact in biomedical research.